ExpErt providErs - for protein production

EUCODIS Bioscience provides customized services in recombinant protein and enzyme production by covering the whole spectrum of bioprocess development up to industrial-scale manufacture of your target proteins.
Our team specializes in developing highyield, high-purity manufacturing processes that are designed to be scalable according to customers’ demand. Customers can rely on EUCODIS as our team works closely with our customers to better understand and meet their individual needs.

EUCODIS will be your reliable partner for: Selection of optimal expression system

  • Fermentation optimization to increase protein yields and stability
  • Professional upscale in scales ranging from 10 L to 1000 L bioreactors
  • Final customized formulation and analysis
  • Complete documentation of all process steps
  • Quality Management according to ISO 9001

Product list

Acceptance Criteria

• Complete inactivation of 1 g beta-lactams (amoxicillin sodium, amoxicillin calavulanate, benzylpenicillin sodium, benzylpenicillin potassium, cefepim, cefotaxim sodium, cefuroxim sodium, cloxacillin, nafcillin, oxacillin sodium,, procain-benzylpenicillin G, piperacillin tazobactam, Ampicillin sodium, cefazolin sodium, ceftazidime sodium carbonate, ceftriaxon disodium, imipenem, meropenem) within 4 hours at room temperature in 1 L medium TSB with a quantity of max. 10 ml of sterile LacBusterTM-L.

• Complete inactivation of 1 g beta-lactams (retarpen) within 24 hours at room temperature in 650 mL medium TSB with a quantity of max. 15 ml of sterile LacBusterTM-L.

• No growth inhibition of the indicator-strains (Bacillus subtilis ATCC 6633,
Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027,
Candida albicans ATCC 10231, Aspergillus brasiliensis ATCC 16404,
Clostridium sporogenes ATCC 11437, Escherichia coli ATCC 8739,
Salmonella typhimurium ATCC 14028) at room temperature (10-100 cfu) in 1 L TSB supplemented with 10 ml of sterile beta lactamase II. Turbidity must be detected within 3 days (5 days for C. albicans and A. brasiliensis).

• Enzyme solution filterable in a temperature range of 2-37°C

• Enzyme activity > 250 IU βI/ml, 100 IU βII/ml (130.000 LU/ml) after storage for at least one year at 2-8°C

• Enzyme activity > 250 IU βI/ml, 100 IU βII/ml (130.000 LU/ml) after storage at room temperature for minimum 1 month

• Enzyme activity > 250 IU βI/ml, 100 IU βII/ml (130.000 LU/ml) and no precipitation after 24 h at 37°C

To download files, see the link below

Application Note Sterility Testing LacBuster_L
Application Note_Acceptance Criteria_LacBuster_L
Datasheet Eucodis Suicide Inhibitors
Eucodis 2013 LacBuste
Eucodis 2013 LacBuster plates
Eucodis 2015 product list
Eucodis Lipase
Eucodis Peroxidase
Eucodis_company profile